RapamycinFungusV1, Main, Exploration, bibRecord, 000716

The TORC1-Sch9-Rim15 signaling pathway represses yeast-to-hypha transition in response to glycerol availability in the oleaginous yeast Yarrowia lipolytica.

Identifieur interne : 000716 ( Main/Exploration ); précédent : 000715; suivant : 000717

The TORC1-Sch9-Rim15 signaling pathway represses yeast-to-hypha transition in response to glycerol availability in the oleaginous yeast Yarrowia lipolytica.

Auteurs : Shu-Heng Liang [République populaire de Chine] ; Heng Wu [République populaire de Chine] ; Rui-Rui Wang [République populaire de Chine] ; Qiang Wang [République populaire de Chine] ; Tao Shu [République populaire de Chine] ; Xiang-Dong Gao [République populaire de Chine]

Source :

Molecular microbiology [ 1365-2958 ] ; 2017.

RBID : pubmed:28188651

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence (MeSH), Fungal Proteins (metabolism), Gene Expression Regulation, Fungal (MeSH), Glucose (metabolism), Glycerol (metabolism), Hyphae (growth & development), Hyphae (metabolism), Mechanistic Target of Rapamycin Complex 1 (MeSH), Multiprotein Complexes (genetics), Multiprotein Complexes (metabolism), Protein-Serine-Threonine Kinases (metabolism), Signal Transduction (MeSH), TOR Serine-Threonine Kinases (genetics), TOR Serine-Threonine Kinases (metabolism), Transcription Factors (metabolism), Yarrowia (genetics), Yarrowia (growth & development), Yarrowia (metabolism).
MESH :
- chemical , genetics : Multiprotein Complexes, TOR Serine-Threonine Kinases.
- chemical , metabolism : Fungal Proteins, Glucose, Glycerol, Multiprotein Complexes, Protein-Serine-Threonine Kinases, TOR Serine-Threonine Kinases, Transcription Factors.
- genetics : Yarrowia.
- growth & development : Hyphae, Yarrowia.
- metabolism : Hyphae, Yarrowia.
- Amino Acid Sequence, Gene Expression Regulation, Fungal, Mechanistic Target of Rapamycin Complex 1, Signal Transduction.

Abstract

The yeast-to-hypha dimorphic transition is important for survival under nutrient starvation in fungi. The oleaginous yeast Yarrowia lipolytica grows in the oval-shaped yeast form in glycerol media whereas it adopts a filamentous form in glucose media. It is not clear why this yeast responds differently to glycerol and glucose. Here, we show that glycerol blocks dimorphic transition even in the presence of glucose whereas glycerol depletion induces filamentous growth, suggesting that dimorphic transition is repressed in response to glycerol availability. We show that the repression of dimorphic transition in glycerol media is mediated by the TORC1-Sch9 signaling pathway as both TORC1 inhibition and the loss of YlSch9 cause hyperfilamentation. TORC1-Sch9 signaling inhibits the nuclear translocation of YlRim15, a protein kinase that positively regulates filamentous growth, preventing it from entering the nucleus to activate the transcription of genes implicated in filamentous growth. Interestingly, TORC1-Sch9 signaling appears not to inhibit YlRim15 in glucose media, which could explain why Y. lipolytica responds differently to glycerol and glucose. We identified MHY1, a transcription factor-encoding gene known to be critical for filamentous growth, as one target regulated by the TORC1-Sch9-Rim15 signaling pathway. Our results provide new insights in the regulation of dimorphic transition in yeast.

DOI: 10.1111/mmi.13645
PubMed: 28188651

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term>
<term>Fungal Proteins (metabolism)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Glucose (metabolism)</term>
<term>Glycerol (metabolism)</term>
<term>Hyphae (growth & development)</term>
<term>Hyphae (metabolism)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (MeSH)</term>
<term>Multiprotein Complexes (genetics)</term>
<term>Multiprotein Complexes (metabolism)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
<term>TOR Serine-Threonine Kinases (genetics)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
<term>Transcription Factors (metabolism)</term>
<term>Yarrowia (genetics)</term>
<term>Yarrowia (growth & development)</term>
<term>Yarrowia (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine (MeSH)</term>
<term>Complexes multiprotéiques (génétique)</term>
<term>Complexes multiprotéiques (métabolisme)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Glucose (métabolisme)</term>
<term>Glycérol (métabolisme)</term>
<term>Hyphae (croissance et développement)</term>
<term>Hyphae (métabolisme)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines fongiques (métabolisme)</term>
<term>Régulation de l'expression des gènes fongiques (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
<term>Sérine-thréonine kinases TOR (génétique)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (MeSH)</term>
<term>Yarrowia (croissance et développement)</term>
<term>Yarrowia (génétique)</term>
<term>Yarrowia (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Multiprotein Complexes</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fungal Proteins</term>
<term>Glucose</term>
<term>Glycerol</term>
<term>Multiprotein Complexes</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>TOR Serine-Threonine Kinases</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Hyphae</term>
<term>Yarrowia</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Yarrowia</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Hyphae</term>
<term>Yarrowia</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Complexes multiprotéiques</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Yarrowia</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hyphae</term>
<term>Yarrowia</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complexes multiprotéiques</term>
<term>Facteurs de transcription</term>
<term>Glucose</term>
<term>Glycérol</term>
<term>Hyphae</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines fongiques</term>
<term>Sérine-thréonine kinases TOR</term>
<term>Yarrowia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Gene Expression Regulation, Fungal</term>
<term>Mechanistic Target of Rapamycin Complex 1</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Régulation de l'expression des gènes fongiques</term>
<term>Séquence d'acides aminés</term>
<term>Transduction du signal</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The yeast-to-hypha dimorphic transition is important for survival under nutrient starvation in fungi. The oleaginous yeast Yarrowia lipolytica grows in the oval-shaped yeast form in glycerol media whereas it adopts a filamentous form in glucose media. It is not clear why this yeast responds differently to glycerol and glucose. Here, we show that glycerol blocks dimorphic transition even in the presence of glucose whereas glycerol depletion induces filamentous growth, suggesting that dimorphic transition is repressed in response to glycerol availability. We show that the repression of dimorphic transition in glycerol media is mediated by the TORC1-Sch9 signaling pathway as both TORC1 inhibition and the loss of YlSch9 cause hyperfilamentation. TORC1-Sch9 signaling inhibits the nuclear translocation of YlRim15, a protein kinase that positively regulates filamentous growth, preventing it from entering the nucleus to activate the transcription of genes implicated in filamentous growth. Interestingly, TORC1-Sch9 signaling appears not to inhibit YlRim15 in glucose media, which could explain why Y. lipolytica responds differently to glycerol and glucose. We identified MHY1, a transcription factor-encoding gene known to be critical for filamentous growth, as one target regulated by the TORC1-Sch9-Rim15 signaling pathway. Our results provide new insights in the regulation of dimorphic transition in yeast.</div>
</front>
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<DateCompleted><Year>2017</Year>
<Month>10</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
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<Issue>4</Issue>
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<Month>05</Month>
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<Title>Molecular microbiology</Title>
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<ArticleTitle>The TORC1-Sch9-Rim15 signaling pathway represses yeast-to-hypha transition in response to glycerol availability in the oleaginous yeast Yarrowia lipolytica.</ArticleTitle>
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<Abstract><AbstractText>The yeast-to-hypha dimorphic transition is important for survival under nutrient starvation in fungi. The oleaginous yeast Yarrowia lipolytica grows in the oval-shaped yeast form in glycerol media whereas it adopts a filamentous form in glucose media. It is not clear why this yeast responds differently to glycerol and glucose. Here, we show that glycerol blocks dimorphic transition even in the presence of glucose whereas glycerol depletion induces filamentous growth, suggesting that dimorphic transition is repressed in response to glycerol availability. We show that the repression of dimorphic transition in glycerol media is mediated by the TORC1-Sch9 signaling pathway as both TORC1 inhibition and the loss of YlSch9 cause hyperfilamentation. TORC1-Sch9 signaling inhibits the nuclear translocation of YlRim15, a protein kinase that positively regulates filamentous growth, preventing it from entering the nucleus to activate the transcription of genes implicated in filamentous growth. Interestingly, TORC1-Sch9 signaling appears not to inhibit YlRim15 in glucose media, which could explain why Y. lipolytica responds differently to glycerol and glucose. We identified MHY1, a transcription factor-encoding gene known to be critical for filamentous growth, as one target regulated by the TORC1-Sch9-Rim15 signaling pathway. Our results provide new insights in the regulation of dimorphic transition in yeast.</AbstractText>
<CopyrightInformation>© 2017 John Wiley & Sons Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liang</LastName>
<ForeName>Shu-Heng</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.</Affiliation>
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<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Heng</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Rui-Rui</ForeName>
<Initials>RR</Initials>
<AffiliationInfo><Affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Qiang</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shu</LastName>
<ForeName>Tao</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Xiang-Dong</ForeName>
<Initials>XD</Initials>
<Identifier Source="ORCID">0000-0002-1008-2324</Identifier>
<AffiliationInfo><Affiliation>Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
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<Month>03</Month>
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<MedlineTA>Mol Microbiol</MedlineTA>
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<ISSNLinking>0950-382X</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D046912">Multiprotein Complexes</NameOfSubstance>
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<NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
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<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
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<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D000076222">Mechanistic Target of Rapamycin Complex 1</NameOfSubstance>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005656" MajorTopicYN="N">Fungal Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005947" MajorTopicYN="N">Glucose</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005990" MajorTopicYN="N">Glycerol</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D025301" MajorTopicYN="N">Hyphae</DescriptorName>
<QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D046912" MajorTopicYN="N">Multiprotein Complexes</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D025062" MajorTopicYN="N">Yarrowia</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>02</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>2</Month>
<Day>12</Day>
<Hour>6</Hour>
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</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>10</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>2</Month>
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<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28188651</ArticleId>
<ArticleId IdType="doi">10.1111/mmi.13645</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Hubei</li>
</region>
<settlement><li>Wuhan</li>
</settlement>
<orgName><li>Université de Wuhan</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Liang, Shu Heng" sort="Liang, Shu Heng" uniqKey="Liang S" first="Shu-Heng" last="Liang">Shu-Heng Liang</name>
</region>
<name sortKey="Gao, Xiang Dong" sort="Gao, Xiang Dong" uniqKey="Gao X" first="Xiang-Dong" last="Gao">Xiang-Dong Gao</name>
<name sortKey="Gao, Xiang Dong" sort="Gao, Xiang Dong" uniqKey="Gao X" first="Xiang-Dong" last="Gao">Xiang-Dong Gao</name>
<name sortKey="Shu, Tao" sort="Shu, Tao" uniqKey="Shu T" first="Tao" last="Shu">Tao Shu</name>
<name sortKey="Wang, Qiang" sort="Wang, Qiang" uniqKey="Wang Q" first="Qiang" last="Wang">Qiang Wang</name>
<name sortKey="Wang, Rui Rui" sort="Wang, Rui Rui" uniqKey="Wang R" first="Rui-Rui" last="Wang">Rui-Rui Wang</name>
<name sortKey="Wu, Heng" sort="Wu, Heng" uniqKey="Wu H" first="Heng" last="Wu">Heng Wu</name>
</country>
</tree>
</affiliations>
</record>

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{{Explor lien
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   |area=    RapamycinFungusV1
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   |clé=     pubmed:28188651
   |texte=   The TORC1-Sch9-Rim15 signaling pathway represses yeast-to-hypha transition in response to glycerol availability in the oleaginous yeast Yarrowia lipolytica.
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	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

The TORC1-Sch9-Rim15 signaling pathway represses yeast-to-hypha transition in response to glycerol availability in the oleaginous yeast Yarrowia lipolytica.

The TORC1-Sch9-Rim15 signaling pathway represses yeast-to-hypha transition in response to glycerol availability in the oleaginous yeast Yarrowia lipolytica.

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